{"title":"PEG Linkers","description":"\u003cp data-pm-slice=\"1 1 []\"\u003e\u003cspan\u003ePolyethylene glycol (PEG) linkers and PEGylation reagents are widely used tools in bioconjugation and drug development to improve the performance of biomolecules and small-molecule therapeutics. PEG linkers consist of flexible, hydrophilic chains of polyethylene glycol that can be functionalized with reactive groups (e.g., NHS esters, maleimides, azides) to enable efficient coupling to proteins, peptides, antibodies, or other payloads. Through PEGylation these reagents help enhance aqueous solubility, reduce aggregation, and minimize non-specific interactions, while also increasing molecular stability and extending systemic circulation half-life by reducing renal clearance and proteolytic degradation. As a result, PEG linkers play a critical role in applications such as antibody–drug conjugates (ADCs), targeted protein degraders (TPDs), nanoparticle and lipid delivery systems, and diagnostic probes, where controlled spacing, flexibility, and biocompatibility are essential for optimal biological performance.\u003c\/span\u003e\u003c\/p\u003e","products":[{"product_id":"aminooxy-peg1-azide","title":"Aminooxy-PEG1-Azide","description":"","brand":"Precise PEG LLC.","offers":[{"title":"100 mg","offer_id":47127999512865,"sku":"AG-1721Q4","price":323.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":47127999545633,"sku":"AG-1721Q5","price":532.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":47127999578401,"sku":"AG-1721Q6","price":836.0,"currency_code":"USD","in_stock":true},{"title":"1 g","offer_id":47127999611169,"sku":"AG-1721Q1","price":1262.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3934\/0321\/files\/Aminooxy-PEG1-Azide-AG-1721_84ea724b-d577-4d8d-8d51-b68f5572d528.png?v=1707244544"},{"product_id":"aminooxy-peg2-azide","title":"Aminooxy-PEG2-Azide","description":"","brand":"Precise PEG LLC.","offers":[{"title":"100 mg","offer_id":47128358388001,"sku":"AG-1722Q4","price":428.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":47128358420769,"sku":"AG-1722Q5","price":618.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":47128358453537,"sku":"AG-1722Q6","price":931.0,"currency_code":"USD","in_stock":true},{"title":"1 g","offer_id":47128358486305,"sku":"AG-1722Q1","price":1406.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3934\/0321\/files\/Aminooxy-PEG2-Azide-AG-1722_3b1e1c81-9950-4819-ac0c-e317dbb3a7e6.png?v=1707244626"},{"product_id":"aminooxy-peg3-azide","title":"Aminooxy-PEG3-Azide","description":"\u003cp class=\"MsoNormal\"\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 0in; text-align: justify; text-justify: inter-ideograph; text-indent: 0in; line-height: 150%; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman';\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e1) \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003eKim, H. C.; et al. Synthesis of Bispecific Antibodies using Genetically Encoded Unnatural Amino Acids. \u003ci\u003eJ. Am. Chem. Soc.\u003c\/i\u003e \u003cb\u003e2012\u003c\/b\u003e, \u003ci\u003e134\u003c\/i\u003e(24), 9918-9921.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 0in; text-align: justify; text-justify: inter-ideograph; line-height: 150%;\"\u003e\u003cb\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003eDOI: \u003c\/span\u003e\u003c\/b\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja303904e\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003e10.1021\/ja303904e\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraphCxSpFirst\" style=\"margin: 0in; mso-add-space: auto; text-align: justify; text-justify: inter-ideograph; line-height: 150%;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eKeywords: \u003c\/span\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003eBispecific Antibodies; Unnatural Amino Acids; Chemical Conjugation; Hydroxylamine\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraphCxSpLast\" style=\"margin: 0in; mso-add-space: auto; text-align: justify; text-justify: inter-ideograph; line-height: 150%;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin: 0in; text-align: justify; text-justify: inter-ideograph; text-indent: 0in; line-height: 150%; mso-list: l0 level1 lfo1;\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman';\"\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e2) \u003c\/span\u003e\u003c\/span\u003e\u003c!--[endif]--\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003eSeki, Y.; et al. Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins. \u003ci\u003eJ. Am. Chem. Soc. \u003c\/i\u003e\u003cb\u003e2016\u003c\/b\u003e, \u003ci\u003e138\u003c\/i\u003e(34), 10798-10801.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" style=\"margin-bottom: 0in; text-align: justify; text-justify: inter-ideograph; line-height: 150%;\"\u003e\u003cb\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003eDOI: \u003c\/span\u003e\u003c\/b\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.6b06692\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003e10.1021\/jacs.6b06692\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoListParagraph\" style=\"margin: 0in; mso-add-space: auto; text-align: justify; text-justify: inter-ideograph; line-height: 150%;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eKeywords: Bioconjugation\u003c\/span\u003e\u003cspan style=\"font-family: 'Times New Roman',serif; mso-fareast-font-family: SimHei;\"\u003e; Chemical Modifications; Proteins; Hydroxylamine\u003c\/span\u003e\u003c\/p\u003e","brand":"Precise PEG LLC.","offers":[{"title":"100 mg","offer_id":47128358519073,"sku":"AG-1723Q4","price":428.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":47128358551841,"sku":"AG-1723Q5","price":618.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":47128358584609,"sku":"AG-1723Q6","price":931.0,"currency_code":"USD","in_stock":true},{"title":"1 g","offer_id":47128358617377,"sku":"AG-1723Q1","price":1406.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3934\/0321\/files\/Aminooxy-PEG3-Azide-AG-1723_7bf3bfa6-df1c-4b75-adf1-06036aee1d6c.png?v=1707244652"},{"product_id":"aminooxy-peg7-azide","title":"Aminooxy-PEG7-Azide","description":"","brand":"Precise 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