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ADC linker Customization
We offer a comprehensive service for the customization of ADC linkers, ensuring they align precisely with your research objectives.
Our capabilities encompass the incorporation of large varieties of linker-payload attachment, linker-antibody attachment, spacer, and peptide/peptidomimetic linkage.
Should you not find a solution that precisely meets your requirements, we invite you to submit an inquiry.
Click Chemistry Reagents Customization
Click chemistry has become a vital tool in research areas such as chemical biology, polymer chemistry, bioconjugation, and drug discovery.
Our comprehensive portfolio of reagents includes azides, alkynes, cyclic alkynes, tetrazine/TCO, and ligands, all designed to accelerate your work in this innovative field. We also offer customization options, such as PEG and peptide linkers, to optimize click reagents tailored to your specific application.
Let us support your research with the right tools for success in the dynamic world of click chemistry.
PEG linker Customization
Our commitment to advancing your research is reflected in our comprehensive service for the customization of PEG linkers. We specialize in crafting solutions that precisely align with your unique objectives, offering flexibility in functionality at chain ends and chain length.
Key Features:
- Customized functionality at chain ends (compatible combinations)
- Adjustable chain length to suit your specific needs.
In the event that you do not find a solution that perfectly aligns with your requirements, we encourage you to submit an inquiry using the form provided. Our dedicated team ensures a lead time of within two weeks for most new linker developments.
Targeted Protein Degrader Customization
Designing effective small-molecule degraders requires precise adjustments to ligands and crosslinkers, as minor modifications can significantly impact binding efficiency. Optimizing linker length, shape, and attachment points is critical for successful PROTAC development.
We offer a versatile collection of crosslinker-E3 ligand conjugates with functional groups that allow flexible attachment to target ligands, which enables rapid library generation and screening.
Additionally, we can produce custom crosslinker-E3ligand conjugates on demand, leveraging the ready availability of diverse crosslinkers and E3 ligands.
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THE PRECISE POST
Insights That Move Science Forward
Explore emerging research, scientific breakthroughs, and expert insights in bioconjugation, linker chemistry, and drug development.
Radionuclide Drug Conjugates (Part 3. Design Principles)
Strategic design framework in RDC development With clinical validation now established, the focus of RDC development is shifting from proof-of-concept to architecture optimization. Successful platforms do not arise from isolated...
What are Chemical Inducers of Proximity (CIPs)?
Chemical inducers of proximity (CIPs) are small molecules that induce proximity between two proteins, promoting protein–protein interactions and thereby regulating cellular processes. This strategy of artificially bringing two proteins together...
Solutions to Deconjugation of Thiol–Maleimide Protein Conjugates
Thiol–maleimide conjugation is currently one of the most widely used conjugation technologies in antibody-drug conjugate (ADC) development. However, the thiosuccinimide linkage formed by this chemistry undergoes two competing reactions in...
Radionuclide Drug Conjugates (Part 2. Clinical Landscapes)
At PrecisePEG, We support this design-driven stage of RDC development through integrated capabilities in chelator-linker engineering, conjugation chemistry, and radiopharmaceutical building blocks, helping translate molecular design principles into stable, scalable,...
Dibromopyridazinedione (DiBrPD) - A New Generation of Thiol-Bridging Site-Specific Conjugation Reagents
Precise PEG® Products Acknowledged in RSC Chemical Biology (2026) Publication Overview A recent publication in RSC Chemical Biology [1] highlights an advanced strategy for the modular, site-selective synthesis of multi-payload...
Radionuclide Drug Conjugates (Part 1. Basic information)
Introduction to Radionuclide Drug Conjugates In the evolving landscape of cancer therapy, precision medicine has become central to achieving maximum efficacy while minimizing systemic toxicity. Among emerging targeted modalities, radionuclide...
Polysarcosine (pSar) as a PEG alternative in Bioconjugation
Introduction: Limitations of PEGylation in modern biologics Polyethylene glycol (PEG) has long been the polymer of choice for improving the solubility, stability, and pharmacokinetics of biologics. PEGylation is widely used...
Glycosidase-Cleavable Linkers in ADC design
At Precise PEG, we focus on the development and production of glycosidase-cleavable linkers for ADC applications, with a portfolio encompassing both β-glucuronidase- and β-galactosidase-cleavable designs. (https://precisepeg.com/collections/novel-enzymes-cleavable-linkers) This coverage enables rational...
Antibody–Drug Conjugates Approved Through November 2025
Antibody–Drug Conjugates (ADCs) are a class of targeted cancer therapies composed of a potent cytotoxic payload chemically linked to a monoclonal antibody (mAb) via a specialized chemical linker. This design...
Peptide Drug Conjugates: Overcoming ADC Limitations in Tumor Targeting
Introduction to Peptide Drug Conjugates Chemotherapy has long been a cornerstone of cancer treatment, yet its lack of selectivity and frequent emergence of resistance significantly limit its long-term efficacy. To...