PEG Tosylate

PEG Tosylate is a PEG reagent characterized by the presence of tosyl groups at the terminus of the PEG chain. Tosyl groups exhibit high reactivity with nucleophiles, including amines, thiols, and alcohols, leading to the formation of stable carbon-nitrogen, carbon-sulfur, or carbon-oxygen bonds. This property enables PEG Tosylate to effectively modify proteins, peptides, or other surfaces possessing amino groups within a pH range of 8.0 to 9.5. Additionally, it facilitates the conjugation of drugs to PEG chains.

The inclusion of the PEG moiety in the molecule imparts solubility in both water and polar organic solvents, endowing hydrophilic properties to the modified compounds. PEG Tosylate finds diverse applications in the realms of chemistry, biochemistry, and materials science, playing a crucial role in bioconjugation, drug delivery, polymer synthesis, and surface modification.

Azido-PEG-OTs

Propargyl-PEG-OTs

m-PEG-OTs