Thiol PEG

Thiol PEG represents a polyethylene glycol (PEG) variant characterized by a sulfhydryl functional group at one terminus. This sulfhydryl moiety exhibits reactivity with various molecules, including other thiols, maleimides, bromoacetamides, SPDP, and gold. Depending on the specific reaction partner, thiol PEG can form disulfide, thioether, or dative bonds with the interacting molecule.

The utility of thiol PEG extends to the modification of surfaces across diverse materials, such as quantum dots, self-assembled monolayers, magnetic particles, and gold nanoparticles (AuNPs). By applying PEG chains to these surfaces, thiol PEG effectively mitigates non-specific protein binding, thereby enhancing biocompatibility and stability. Additionally, thiol PEG serves as a valuable reagent for the modification of proteins, peptides, and other biomolecules through the attachment of PEG chains.

Thiol PEG emerges as a versatile tool for surface and biomolecule functionalization, finding significant application in the realms of bionanotechnology and nanomedicine. Its diverse reactivity and compatibility make it a pivotal component in advancing these fields.

Amino-PEG-Thiol

Azido-PEG-Thiol

Ethanethioate-PEG-Propargyl

Propargyl-PEG-Thiol

m-PEG-Ethanethioate

m-PEG-Thiol