Aminooxy PEG

Aminooxy PEGs, also referred to as oxyamine PEGs, comprise a distinct category of polyethylene glycol compounds distinguished by aminooxy end groups. These specialized groups demonstrate reactivity with aldehydes or ketones, leading to the formation of oxime bonds. This conjugation technique is notable for its reliability and versatility, attributed to its mild reaction conditions, high chemoselectivity, and the hydrolytic stability inherent to oxime bonds. Oxime ligation has proven successful in the preparation of various bioconjugates, including polymer-proteins, peptide dendrimers, oligonucleo-peptides, glycoconjugates, protein–protein probes, 18F-PET tracers, and hydrogels.

Heterobifunctional aminooxy PEGs enhance versatility by incorporating a range of functional groups, such as Amine (NH₂), Carboxylic Acid (COOH), Thiol (SH), Azide (N₃), NHS ester, Maleimide (Mal), Alkyne, Biotin, DBCO, among others. This broad array of functional groups underscores the adaptability and applicability of aminooxy PEGs in various bioconjugation scenarios.

Aminooxy-PEG-Acid

Aminooxy-PEG-Azide

Aminooxy-PEG-CH2COOH

Aminooxy-PEG-Propargyl

Boc Aminooxy-PEG-Azide

Fmoc-Aminooxy-PEG-Acid

N-Boc-Aminooxy-PEG-Acid

N-Boc-Aminooxy-PEG-CH2COOH

m-PEG-Aminooxy