Collection: PEG Mesylate
PEG Mesylate is a PEG reagent distinguished by the presence of mesyl groups (methanesulfonyl, abbreviated as OMs) located at the terminus of the PEG chain. The mesyl group serves as an effective leaving group in nucleophilic substitution reactions (SN2), enabling reactivity with amines, thiols, and alcohols to yield stable carbon-nitrogen, carbon-sulfur, or carbon-oxygen bonds. This property allows PEG Mesylate to adeptly modify proteins, peptides, or other surfaces containing amino groups, as well as facilitate the conjugation of drugs to PEG chains.
In comparison to PEG Tosylate, PEG Mesylate exhibits higher reactivity but lower stability. Despite its reactivity, it remains soluble in water and polar organic solvents. PEG Mesylate finds diverse applications across the domains of chemistry, biochemistry, and materials science, playing a pivotal role in bioconjugation, drug delivery, polymer synthesis, and surface modification.
