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Targeted Protein Degrader Building Blocks

The concurrent binding of a degrader molecule to two proteins—the protein of interest (POI) and an E3 ubiquitin ligase—enables the E3 ligase to recruit the E2 enzyme, initiating polyubiquitination of the POI. This post-translational modification flags the POI for targeted degradation via the proteasome, a central pathway in cellular regulation.

The design of effective PROTACs (proteolysis-targeting chimeras) demands precise control over linker length, shape, and attachment points to optimize binding affinity and functional efficacy. However, the heterobifunctional nature of PROTACs introduces considerable synthetic challenges, and computational tools often fall short in accurately predicting structure-activity relationships (SAR). Consequently, SAR exploration is primarily empirical, necessitating substantial investments of time and resources.

To address the challenges associated with PROTAC design and accelerate development, we have established a robust library of pre-formed E3-ligand linker intermediates. This resource enables the efficient synthesis of a wide array of diverse PROTAC candidates, facilitating their rapid evaluation and optimization for targeted protein degradation applications.

1192 Results

1192 Results

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1-(6-bromo-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione

1-(6-bromo-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione

from $390

from $390

3-(1-methyl-6-(piperidin-4-yl)-1H-indazol-3-yl)piperidine-2,6-dione hydrochloride

3-(1-methyl-6-(piperidin-4-yl)-1H-indazol-3-yl)piperidine-2,6-dione hydrochloride

from $490

from $490

3-(5-(4-acryloyl-2-oxopiperazin-1-yl)furan-2-yl)propanoic acid

3-(5-(4-acryloyl-2-oxopiperazin-1-yl)furan-2-yl)propanoic acid

from $720

from $720

2-(4-(2-(5-(3,5-dimethylisoxazol-4-yl)-1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-2-fluorophenoxy)ethan-1-amine

2-(4-(2-(5-(3,5-dimethylisoxazol-4-yl)-1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-2-fluorophenoxy)ethan-1-amine

from $1,080

from $1,080

3-(isoindolin-5-yl)piperidine-2,6-dione hydrochloride

3-(isoindolin-5-yl)piperidine-2,6-dione hydrochloride

from $650

from $650

5-((4-aminocyclohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

5-((4-aminocyclohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

from $1,080

from $1,080

(S)-3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $980

from $980

ethyl (Z)-5-(3-hydroxy-4-methoxybenzylidene)-4-oxo-2-(phenylamino)-4,5-dihydrothiophene-3-carboxylate

ethyl (Z)-5-(3-hydroxy-4-methoxybenzylidene)-4-oxo-2-(phenylamino)-4,5-dihydrothiophene-3-carboxylate

from $850

from $850

(S)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-7-hydroxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

(S)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-7-hydroxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

from $850

from $850

12-azidododecanoic acid

12-azidododecanoic acid

from $470

from $470

18-Azido-stearic acid 

18-Azido-stearic acid 

from $350

from $350

3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazole-6-carbaldehyde

3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazole-6-carbaldehyde

from $540

from $540

5-(4-(azetidin-3-yl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate

5-(4-(azetidin-3-yl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate

from $280

from $280

3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoic acid

3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoic acid

from $320

from $320

1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)piperidine-4-carboxylic acid hydrochloride

1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)piperidine-4-carboxylic acid hydrochloride

from $650

from $650

3-(5-(azetidin-3-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione TFA salt

3-(5-(azetidin-3-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione TFA salt

from $480

from $480

1-ethyl-2-((E)-((Z)-3-ethyl-5-(6-hydroxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
New

1-ethyl-2-((E)-((Z)-3-ethyl-5-(6-hydroxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride

from $1,480

from $1,480

3-((1-(3-aminopropyl)-2,4-dioxo-3-(4-(trifluoromethyl)benzyl)-1,3,4,5,7,8-hexahydropyrido[4,3-d]pyrimidin-6(2H)-yl)methyl)benzonitrile
New

3-((1-(3-aminopropyl)-2,4-dioxo-3-(4-(trifluoromethyl)benzyl)-1,3,4,5,7,8-hexahydropyrido[4,3-d]pyrimidin-6(2H)-yl)methyl)benzonitrile

from $1,450

from $1,450

1-(2-aminoethyl)-2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium 2,2,2-trifluoroacetate
New

1-(2-aminoethyl)-2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium 2,2,2-trifluoroacetate

from $1,480

from $1,480

2-((Z)-((E)-5-(6-amino-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)-1-ethylpyridin-1-ium 2,2,2-trifluoroacetate
New

2-((Z)-((E)-5-(6-amino-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)-1-ethylpyridin-1-ium 2,2,2-trifluoroacetate

from $1,650

from $1,650

DCAF1 binder 1
New

DCAF1 binder 1

from $1,050

from $1,050

(E)-3-(5-(6-(4-(dimethylamino)but-2-enoyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)thiophen-2-yl)propanoic acid
New

(E)-3-(5-(6-(4-(dimethylamino)but-2-enoyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)thiophen-2-yl)propanoic acid

from $1,580

from $1,580

5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pent-4-ynoic acid
New

5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pent-4-ynoic acid

from $1,450

from $1,450

8-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)oct-7-ynoic acid
New

8-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)oct-7-ynoic acid

from $1,450

from $1,450

tert-butyl (((2R,3S)-2-(4-aminophenyl)tetrahydrofuran-3-yl)methyl)((3-phenyl-1H-pyrazol-4-yl)methyl)carbamate
New

tert-butyl (((2R,3S)-2-(4-aminophenyl)tetrahydrofuran-3-yl)methyl)((3-phenyl-1H-pyrazol-4-yl)methyl)carbamate

from $1,750

from $1,750

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((4-(piperazin-1-yl)phenyl)amino)benzamide
New

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((4-(piperazin-1-yl)phenyl)amino)benzamide

from $1,280

from $1,280

tert-butyl (((2R,3S)-2-(4-(aminomethyl)phenyl)tetrahydrofuran-3-yl)methyl)((3-phenyl-1H-pyrazol-4-yl)methyl)carbamate
New

tert-butyl (((2R,3S)-2-(4-(aminomethyl)phenyl)tetrahydrofuran-3-yl)methyl)((3-phenyl-1H-pyrazol-4-yl)methyl)carbamate

from $1,750

from $1,750

2-(4-(4-(((tert-butoxycarbonyl)(((2R,3S)-2-phenyltetrahydrofuran-3-yl)methyl)amino)methyl)-1H-pyrazol-3-yl)phenyl)acetic acid
New

2-(4-(4-(((tert-butoxycarbonyl)(((2R,3S)-2-phenyltetrahydrofuran-3-yl)methyl)amino)methyl)-1H-pyrazol-3-yl)phenyl)acetic acid

from $1,750

from $1,750

2-(4-(4-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-(ethylcarbamoyl)-4H-1,2,4-triazol-4-yl)benzyl)piperazin-1-yl)acetic acid
New

2-(4-(4-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-(ethylcarbamoyl)-4H-1,2,4-triazol-4-yl)benzyl)piperazin-1-yl)acetic acid

from $1,380

from $1,380

5-(3,5-dihydroxy-2-isopropylphenyl)-N-ethyl-4-(4-(piperazin-1-ylmethyl)phenyl)-4H-1,2,4-triazole-3-carboxamide
New

5-(3,5-dihydroxy-2-isopropylphenyl)-N-ethyl-4-(4-(piperazin-1-ylmethyl)phenyl)-4H-1,2,4-triazole-3-carboxamide

from $1,350

from $1,350

1-(4-(2-((2-amino-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-6-yl)amino)ethyl)piperidin-1-yl)-2-azidoethan-1-one
New

1-(4-(2-((2-amino-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-6-yl)amino)ethyl)piperidin-1-yl)-2-azidoethan-1-one

from $1,350

from $1,350

1-(2-(1-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl)piperidin-4-yl (4-nitrophenyl) carbonate
New

1-(2-(1-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl)piperidin-4-yl (4-nitrophenyl) carbonate

from $1,350

from $1,350

4-(3-(2-(4-hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile
New

4-(3-(2-(4-hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile

from $1,200

from $1,200

(1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)piperidin-4-yl)methyl (4-nitrophenyl) carbonate
New

(1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)piperidin-4-yl)methyl (4-nitrophenyl) carbonate

from $1,350

from $1,350

(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)(4-(hydroxymethyl)piperidin-1-yl)methanone
New

(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)(4-(hydroxymethyl)piperidin-1-yl)methanone

from $1,200

from $1,200

(4-(azidomethyl)piperidin-1-yl)(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methanone
New

(4-(azidomethyl)piperidin-1-yl)(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methanone

from $1,580

from $1,580

(R)-1-(4-([4,4'-bipiperidin]-1-yl)phenyl)-5-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
New

(R)-1-(4-([4,4'-bipiperidin]-1-yl)phenyl)-5-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

from $1,480

from $1,480

(R)-5-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-1-(4-(piperazin-1-yl)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
New

(R)-5-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-1-(4-(piperazin-1-yl)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

from $1,480

from $1,480

3-((2-((2-aminoethyl)(methyl)amino)ethyl)amino)-6-(cyclohexylthio)-1-oxo-1H-phenalene-2-carbonitrile
New

3-((2-((2-aminoethyl)(methyl)amino)ethyl)amino)-6-(cyclohexylthio)-1-oxo-1H-phenalene-2-carbonitrile

from $1,450

from $1,450

4-(3-(4-(3-azaspiro[5.5]undecane-9-carbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
New

4-(3-(4-(3-azaspiro[5.5]undecane-9-carbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

from $1,280

from $1,280

4-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-4-oxobutanoic acid
New

4-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-4-oxobutanoic acid

from $1,280

from $1,280

(5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carbonyl)glycine
New

(5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carbonyl)glycine

from $1,850

from $1,850

2-((6-((2-chloro-5-((3-(fluorosulfonyl)benzyl)amino)phenyl)amino)-8-methoxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)acetic acid
New

2-((6-((2-chloro-5-((3-(fluorosulfonyl)benzyl)amino)phenyl)amino)-8-methoxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)acetic acid

from $1,980

from $1,980

5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxylic acid
New

5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxylic acid

from $1,790

from $1,790

(S,E)-3-(4-((3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl)carbamoyl)-3-(4-chloro-2-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)acrylic acid
New

(S,E)-3-(4-((3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl)carbamoyl)-3-(4-chloro-2-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)acrylic acid

from $1,790

from $1,790

(S,E)-3-(4-((3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl)carbamoyl)-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl)acrylic acid
New

(S,E)-3-(4-((3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl)carbamoyl)-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl)acrylic acid

from $1,980

from $1,980

3-(1-methyl-2-oxo-1,2-dihydro-3H,6H-spiro[benzofuro[5,6-d]imidazole-7,4'-piperidin]-3-yl)piperidine-2,6-dione
New

3-(1-methyl-2-oxo-1,2-dihydro-3H,6H-spiro[benzofuro[5,6-d]imidazole-7,4'-piperidin]-3-yl)piperidine-2,6-dione

from $1,580

from $1,580

(S)-3-((R)-6-oxo-1,7-diazaspiro[4.4]nonan-7-yl)piperidine-2,6-dione
New

(S)-3-((R)-6-oxo-1,7-diazaspiro[4.4]nonan-7-yl)piperidine-2,6-dione

from $1,980

from $1,980

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