Collection: PEG Aldehyde

PEG Aldehyde constitutes a category of PEG derivatives featuring an aldehyde group at one terminus. This specialized PEG linker facilitates the modification of biomolecules through reactions with amines. Aldehydes, inherent to PEG Aldehyde, engage in the formation of imines with C=N bonds, reacting specifically with the N-terminal or amine of a peptide or protein. These initial imines can be subsequently reduced to establish more stable C-N bonds. Consequently, PEG Aldehyde emerges as a valuable reagent for site-specific pegylation, capitalizing on the lower pKa of the N-terminal amine to pegylate proteins/peptides at their amino groups on the N-terminus.

Moreover, PEG Aldehyde finds application in bioconjugation endeavors by reacting its aldehyde group with aminooxy or hydrazide groups. The reversible nature of the conjugation is achieved by reacting with hydrazine or hydrazide groups, forming a hydrolytically labile acyl hydrazone linkage. This versatile functionality positions PEG Aldehyde as a pivotal tool for precise and controlled modifications in bioconjugation and pegylation strategies.