Amino PEG

Amino PEG, or PEG amine, constitutes a diverse class of compounds with notable synthetic significance. Distinguished by an amine endgroup, these compounds manifest versatile reactivity, participating in reactions with carboxylic acid-containing compounds to generate a range of amides. Additionally, they engage with activated esters, encompassing N-hydroxysuccinimide esters, pentafluorophenyl (PFP) esters, and para-nitrophenyl esters, leading to the formation of amides incorporating a PEG unit. The process of PEGylation, facilitated by amino PEG, proves efficacious in enhancing aqueous solubility and chemical stability, while concurrently mitigating immunogenicity of peptides and proteins. This functionalization also serves to avert nonspecific binding of charged molecules to modified surfaces, further underscoring the utility of amino PEG in bioconjugation and pharmaceutical applications.