PEG sulfonic acid represents a class of polyethylene glycol (PEG) derivatives characterized by a sulfonic acid end group. These derivatives exhibit diverse functional groups at the other end, such as amine, carboxylic acid, thiol, azide, NHS ester, maleimide, alkyne, and more. The sulfonic acid component contributes to the compound's heightened aqueous solubility. Leveraging its capabilities in esterification, halogenation, and replacement reactions, PEG sulfonic acid finds frequent application in pharmaceutical research as a linker molecule. It facilitates the conjugation of drugs or bioactive molecules to targeting agents like antibodies or peptides, leading to the creation of bioconjugates with enhanced pharmacokinetics, heightened specificity, and reduced immunogenicity. These attributes make PEG sulfonic acid promising for applications in drug delivery and imaging.
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