Collection: PEG PFP Ester

PEG PFP esters, a subset of amine-reactive PEG reagents, are PEG derivatives featuring a pentafluorophenoyl (PFP) activated carboxylic acid at one end. This functional group facilitates the formation of amide bonds with both primary and secondary amines, making it suitable for labeling the amino groups of proteins, amine-modified oligonucleotides, and other amine-containing molecules. In comparison to PEG NHS ester, PFP ester exhibits reduced susceptibility to hydrolysis, resulting in enhanced stability in aqueous solutions and more efficient reactions.

Similar to NHS esters, PEG PFP esters find widespread use in bioconjugation and the modification of biomolecules such as proteins, peptides, antibodies (ADC), and amine-modified oligonucleotides. Their rapid and facile capacity to modify the surfaces of these biomolecules is particularly valuable for applications in targeted drug delivery. Furthermore, PEG PFP esters can be employed to label the surfaces of nanoparticles and cells.