Dinitrophenyl (DNP) serves as a hapten and stands among the early small molecules utilized to elicit specific and targeted endogenous antibody-mediated responses. Antibodies generated against DNP exhibit heightened affinities in comparison to other antibodies toward their respective targets, rendering DNP highly favorable as an affinity tag for oligonucleotides. Notably, DNP emerges as an excellent alternative to biotin in applications requiring systems devoid of biotin.
PrecisePEG presents a range of DNP PEG reagents featuring diverse active groups, including carboxylic acid, hydroxyl, azide, NHS ester, among others. The hydrophilic nature of the PEG linker facilitates an increased number of DNP groups to be conjugated to a biological molecule without inducing precipitation, thus enhancing the efficacy of bioconjugation processes.
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