Collection: PEG Hydrazide

PEG Hydrazide, a subset of PEG reagents, features a hydrazide functional group, enabling reactions with aldehydes, ketones, or carboxyl moieties. This characteristic facilitates the attachment of various molecules, including drugs, peptides, and proteins. Notably, PEG Hydrazide is adept at reversible bioconjugation, forming an acyl hydrazone linkage bond with ketones or aldehydes, a process sensitive to pH variations.

The pH-sensitive nature of PEG hydrazone conjugates, coupled with controlled pH-sensitivity, holds promise for applications in biological stimuli-mediated drug targeting. Additionally, the hydrazide group exhibits reactivity with carbonyl groups, forming diacylhydrazide linkages, commonly employed in the PEGylation of glycosylated sites on proteins. Another notable application involves the creation of lipidated hydrazide PEG nanoparticles, characterized by self-assembling lipids encapsulating drugs, with hydrazide PEG contributing to enhanced stability, biocompatibility, and controlled drug release.

The utility of Hydrazide PEG reagents extends to drug research and development, featuring diverse applications in diagnostics and therapeutic protein modification, making them valuable tools in advancing pharmaceutical sciences.