Bromoacetamide PEG

Bromoacetamide PEG, a PEG derivative featuring a bromoacetamide group, is a versatile reagent for the conjugation of two distinct proteins or an antibody with a payload. This conjugation involves the reaction of the bromoacetamide group with a free thiol, utilizing the bromide (Br) as an excellent leaving group for nucleophilic substitution reactions. The reactive bromoacetamide group specifically interacts with free sulfhydryl groups (-SH) in proteins or peptides through thiol-alkylation, resulting in the formation of covalent conjugates. The presence of the bromoacetamide group allows for selective modification of proteins or other biomolecules through nucleophilic substitution reactions, commonly employed in creating conjugates for various applications such as drug delivery, imaging, and diagnostics. Additionally, Bromoacetamide PEG serves as a crosslinking agent and linker, facilitating the conjugation of other molecules to proteins or peptides. Its applications extend to the preparation of hydrogels, surface coatings, and various materials within biomedical and pharmaceutical contexts.