BCN PEG

The strain-promoted alkyne-azide cycloaddition (SPAAC) stands out as a widely adopted bioorthogonal reaction with extensive applications across diverse fields, owing to its notable attributes of high efficiency, rapidity, selectivity, and bioorthogonality. Importantly, SPAAC reactions do not necessitate additional stimuli such as light, heat, ultrasound, or catalysts. The impetus for the reaction arises from the inherent strain in the active cyclic alkynes. Over the years, various cyclooctyne derivatives, including BCN (bicyclo[6.1.0]nonyne), have been developed and scrutinized for their reactivity in SPAAC reactions with azides.

BCN PEG represents a click chemistry linker featuring a highly reactive BCN group at one end, coupled with polyethylene glycol. Among diverse cyclooctynes, BCN strikes a favorable balance between reactivity and hydrophilicity. Its exceptional reactivity, solubility, and chemoselectivity render it well-suited for applications in bioconjugations, labeling, and chemical biology in aqueous environments. BCN PEG serves as a valuable tool for imaging and tracking biomolecules, including proteins, lipids, and glycans, within their natural milieu.

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