CRBN Ligand-Linker | PROTAC Conjugates for Degrader Design – Page 19

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tert-butyl 3-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)azetidine-1-carboxylate

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tert-butyl 3-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)azetidine-1-carboxylate

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tert-butyl 3-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)pyrrolidine-1-carboxylate

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tert-butyl 3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)azetidine-1-carboxylate

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tert-butyl 3-(piperazin-1-yl)pyrrolidine-1-carboxylate

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tert-butyl 3-bromo-2,6-dioxo-piperidine-1-carboxylate

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tert-butyl 4-(1-(2,6-dioxopiperidin-3-yl)-6-oxo-1,6-dihydropyridazin-3-yl)piperazine-1-carboxylate

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tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)piperazine-1-carboxylate

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tert-butyl 4-(2-(piperazin-1-yl)ethyl)piperidine-1-carboxylate

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tert-butyl 4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)piperazine-1-carboxylate

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tert-butyl 4-(4-((2,4-dioxo-3-azabicyclo[3.1.1]heptan-1-yl)amino)phenyl)piperazine-1-carboxylate

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tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)-2-fluorophenyl)piperazine-1-carboxylate

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tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)-3-methoxyphenyl)piperazine-1-carboxylate

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tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)carbamoyl)-3-fluorophenyl)piperazine-1-carboxylate

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tert-butyl 4-(4-(2,6-dioxopiperidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate

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tert-butyl 4-(4-(2,6-dioxopiperidin-3-yl)-3-fluorophenyl)piperazine-1-carboxylate

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tert-butyl 4-(4-(2,6-dioxopiperidin-3-yl)-3-methoxyphenyl)piperazine-1-carboxylate

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tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate

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tert-butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate

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tert-butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate

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tert-butyl 6-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

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CRBN Ligand-Linker Conjugate

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tert-butyl 3-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)azetidine-1-carboxylate

tert-butyl 3-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)azetidine-1-carboxylate

tert-butyl 3-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)pyrrolidine-1-carboxylate

tert-butyl 3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)azetidine-1-carboxylate

tert-butyl 3-(piperazin-1-yl)pyrrolidine-1-carboxylate

tert-butyl 3-bromo-2,6-dioxo-piperidine-1-carboxylate

tert-butyl 4-(1-(2,6-dioxopiperidin-3-yl)-6-oxo-1,6-dihydropyridazin-3-yl)piperazine-1-carboxylate

tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)piperazine-1-carboxylate

tert-butyl 4-(2-(piperazin-1-yl)ethyl)piperidine-1-carboxylate

tert-butyl 4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)piperazine-1-carboxylate

tert-butyl 4-(4-((2,4-dioxo-3-azabicyclo[3.1.1]heptan-1-yl)amino)phenyl)piperazine-1-carboxylate

tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)-2-fluorophenyl)piperazine-1-carboxylate

tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)-3-methoxyphenyl)piperazine-1-carboxylate

tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)carbamoyl)-3-fluorophenyl)piperazine-1-carboxylate

tert-butyl 4-(4-(2,6-dioxopiperidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate

tert-butyl 4-(4-(2,6-dioxopiperidin-3-yl)-3-fluorophenyl)piperazine-1-carboxylate

tert-butyl 4-(4-(2,6-dioxopiperidin-3-yl)-3-methoxyphenyl)piperazine-1-carboxylate

tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate

tert-butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate

tert-butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate

tert-butyl 6-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

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