Collection: DOTA PEG

DOTA PEG represents a distinct category of PEG linker featuring a DOTA (1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid) unit coupled with a linear polyethylene glycol (PEG) chain. The macrocycle DOTA is recognized as an exceptional and versatile metal chelator, particularly prevalent in PET and SPECT imaging as well as radiotherapy applications. The incorporation of a PEG chain within the linker contributes to the stability and solubility of the conjugate.

Applications of DOTA-PEG linkers encompass:

1. Development of targeted molecular imaging and therapy: Attaching the DOTA PEG linker to a targeting molecule, such as an antibody or a small molecule ligand, enables the selective delivery of therapeutic agents to specific cells or tissues in the body.

2. Advancements in novel therapeutics for cancer, neurological disorders, and inflammatory diseases: DOTA-PEG linkers play a pivotal role in enhancing the pharmacokinetic properties of drug conjugates, including increased half-life and reduced immunogenicity. These attributes contribute to the development of more effective and well-tolerated therapeutic interventions.