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Maleimide PEG

Maleimide PEG, a subset of polyethylene glycol (PEG), features a maleimide group at one terminal end, serving as an effective handle for streamlined functionalization through thiol–maleimide conjugation and Diels–Alder cycloaddition click reactions.

The expeditious and straightforward reaction between a thiol and a maleimide, leading to the formation of a thiosuccinimide product, has emerged as a preeminent method for site-selective modification of cysteine residues within the realm of bioconjugation technology. Within the pH range of 6.5 to 7.5, the thiol-maleimide reaction demonstrates chemoselectivity for thiols and engenders stable thioether bonds. It is noteworthy that beyond pH 7.5, free primary amines competitively react at the maleimide double bond. PEG Maleimide proves invaluable for bioconjugation and protein labeling endeavors, offering the capability to affix small molecules with PEG chains to proteins, peptides, or surfaces featuring sulfhydryl groups. This versatile application underscores the utility of Maleimide PEG in facilitating precise and controlled modifications in diverse biotechnological contexts.

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View all... Acrylate PEG Alcohol PEG Amino PEG Aminooxy PEG Aryl PEG Azido PEG BCN PEG Biotin PEG Bromo PEG Bromoacetamide PEG DBCO PEG DNP PEG DOTA PEG DOTAGA PEG m-PEG Maleimide PEG PEG Acid PEG Aldehyde PEG CH2COOH Acid PEG Fluorescent Dye PEG Hydrazide PEG Mesylate PEG NHS Ester PEG PFP Ester PEG Phosphonate PEG Phosphonic Acid PEG SDP Ester PEG Silane PEG Sulfonic Acid PEG TFP Ester PEG Tosylate PPG Derivatives Propargyl PEG SPDP PEG TCO PEG Tetrazine PEG Thiol PEG Mono-dispersed PEG2000 (PEG45) Branched PEG

PEG Derivatives by Application (Reactivity)

Amine reactive PEG derivatives Bifunctional x-Arm PEG Biotinylation PEG derivatives Carbonyl reactive PEGs Carboxyl reactive PEGs Click chemistry PEGs DOTA chelator PEGs Drug delivery PEGs Dye labeling PEGs Nanoparticle PEGylation Peptide and Protein PEGylation Polymerizable PEGs Specialty PEGylation reagents Surface Reactive PEG Derivatives Thiol reactive PEG derivatives Thiol-ene Crosslinker Chemistry
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t-Boc-Amido-PEG4-Mal

t-Boc-Amido-PEG4-Mal

from $440.00

from $440.00

t-Boc-Amido-PEG5-Mal

t-Boc-Amido-PEG5-Mal

from $440.00

from $440.00

t-Boc-Amido-PEG6-Mal

t-Boc-Amido-PEG6-Mal

from $540.00

from $540.00

t-Boc-Amido-PEG7-Mal

t-Boc-Amido-PEG7-Mal

from $590.00

from $590.00

t-Boc-Amido-PEG8-Mal

t-Boc-Amido-PEG8-Mal

from $620.00

from $620.00

t-Boc-Amido-PEG9-Mal

t-Boc-Amido-PEG9-Mal

from $650.00

from $650.00

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