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Targeted Protein Degrader Building Blocks

The concurrent binding of a degrader molecule to two proteins—the protein of interest (POI) and an E3 ubiquitin ligase—enables the E3 ligase to recruit the E2 enzyme, initiating polyubiquitination of the POI. This post-translational modification flags the POI for targeted degradation via the proteasome, a central pathway in cellular regulation.

The design of effective PROTACs (proteolysis-targeting chimeras) demands precise control over linker length, shape, and attachment points to optimize binding affinity and functional efficacy. However, the heterobifunctional nature of PROTACs introduces considerable synthetic challenges, and computational tools often fall short in accurately predicting structure-activity relationships (SAR). Consequently, SAR exploration is primarily empirical, necessitating substantial investments of time and resources.

To address the challenges associated with PROTAC design and accelerate development, we have established a robust library of pre-formed E3-ligand linker intermediates. This resource enables the efficient synthesis of a wide array of diverse PROTAC candidates, facilitating their rapid evaluation and optimization for targeted protein degradation applications.

1050 Results

1050 Results

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6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide

6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide

from $540.00

from $540.00

6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanoic acid

6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanoic acid

from $355.00

from $355.00

6-(2,6-bis(benzyloxy)pyridin-3-yl)-3-chloro-7-methyl-7H-pyrrolo[2,3-c]pyridazine

6-(2,6-bis(benzyloxy)pyridin-3-yl)-3-chloro-7-methyl-7H-pyrrolo[2,3-c]pyridazine

from $1,080.00

from $1,080.00

6-(2-(1-methyl-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)hex-5-ynoic acid

6-(2-(1-methyl-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)hex-5-ynoic acid

from $900.00

from $900.00

6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hex-5-ynoic acid

6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hex-5-ynoic acid

from $900.00

from $900.00

6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanoic acid

6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanoic acid

from $1,080.00

from $1,080.00

6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)hex-5-ynoic acid

6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)hex-5-ynoic acid

from $1,080.00

from $1,080.00

6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-ynoic acid

6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-ynoic acid

from $980.00

from $980.00

6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)hex-5-ynoic acid

6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)hex-5-ynoic acid

from $980.00

from $980.00

6-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-4-yl)hex-5-ynoic acid

6-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-4-yl)hex-5-ynoic acid

from $980.00

from $980.00

6-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)hex-5-ynoic acid

6-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)hex-5-ynoic acid

from $900.00

from $900.00

6-(3-(dimethoxymethyl)azetidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-4-methoxyisoindoline-1,3-dione

6-(3-(dimethoxymethyl)azetidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-4-methoxyisoindoline-1,3-dione

from $1,080.00

from $1,080.00

6-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)hexanoic acid

6-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)hexanoic acid

from $840.00

from $840.00

6-(4-(dimethoxymethyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-4-methoxyisoindoline-1,3-dione

6-(4-(dimethoxymethyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-4-methoxyisoindoline-1,3-dione

from $1,080.00

from $1,080.00

6-(6-azidohexanamido)hexanoic acid

6-(6-azidohexanamido)hexanoic acid

from $980.00

from $980.00

6-(benzyloxy)-6-oxohexanoic acid

6-(benzyloxy)-6-oxohexanoic acid

from $670.00

from $670.00

6-azidohexanoic acid

6-azidohexanoic acid

from $390.00

from $390.00

6-bromo-3-iodo-2-methyl-2H-indazole

6-bromo-3-iodo-2-methyl-2H-indazole

from $785.00

from $785.00

7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hept-6-ynoic acid

7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hept-6-ynoic acid

from $900.00

from $900.00

7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)heptyl 4-methylbenzenesulfonate

7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)heptyl 4-methylbenzenesulfonate

from $750.00

from $750.00

7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hept-6-ynoic acid

7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hept-6-ynoic acid

from $980.00

from $980.00

7-benzyl-4-(4-bromobenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

7-benzyl-4-(4-bromobenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

from $980.00

from $980.00

8-(2-(1-methyl-2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)oct-7-ynoic acid

8-(2-(1-methyl-2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)oct-7-ynoic acid

from $980.00

from $980.00

8-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oct-7-ynoic acid

8-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oct-7-ynoic acid

from $900.00

from $900.00

8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-ynoic acid

8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-ynoic acid

from $900.00

from $900.00

8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)oct-7-ynoic acid

8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)oct-7-ynoic acid

from $900.00

from $900.00

8-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-4-yl)oct-7-ynoic acid

8-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-4-yl)oct-7-ynoic acid

from $980.00

from $980.00

8-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)oct-7-ynoic acid

8-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)oct-7-ynoic acid

from $900.00

from $900.00

8-(6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)octanoic acid

8-(6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)octanoic acid

from $840.00

from $840.00

8-Azido-octanoyl-OSu

8-Azido-octanoyl-OSu

from $325.00

from $325.00

9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-N6-(2-(piperidin-4-yl)ethyl)-9H-purine-2,6-diamine

9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-N6-(2-(piperidin-4-yl)ethyl)-9H-purine-2,6-diamine

from $1,280.00

from $1,280.00

9-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)non-8-ynoic acid

9-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)non-8-ynoic acid

from $900.00

from $900.00

9-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)non-8-ynoic acid

9-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)non-8-ynoic acid

from $980.00

from $980.00

9-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)nonanoic acid

9-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)nonanoic acid

from $580.00

from $580.00

9-azidononanoic acid

9-azidononanoic acid

from $735.00

from $735.00

Ald-Ph-NHS ester

Ald-Ph-NHS ester

from $480.00

from $480.00

AP1867

AP1867

from $580.00

from $580.00

AP1867-3-(aminoethoxy)

AP1867-3-(aminoethoxy)

from $960.00

from $960.00

AP1867-7-AhpA-(S,R,S)-AHPC

AP1867-7-AhpA-(S,R,S)-AHPC

from $840.00

from $840.00

BCL6 ligand-1

BCL6 ligand-1

from $840.00

from $840.00

benzyl ((2R,4S)-1-(L-alanyl)-4-hydroxypyrrolidine-2-carbonyl)-L-tyrosyl-L-isoleucinate

benzyl ((2R,4S)-1-(L-alanyl)-4-hydroxypyrrolidine-2-carbonyl)-L-tyrosyl-L-isoleucinate

from $840.00

from $840.00

benzyl ((2S,4R)-1-(L-leucyl-L-alanyl)-4-hydroxypyrrolidine-2-carbonyl)-L-tyrosyl-L-isoleucinate

benzyl ((2S,4R)-1-(L-leucyl-L-alanyl)-4-hydroxypyrrolidine-2-carbonyl)-L-tyrosyl-L-isoleucinate

from $840.00

from $840.00

bis(2,5-dioxopyrrolidin-1-yl) glutarate

bis(2,5-dioxopyrrolidin-1-yl) glutarate

from $580.00

from $580.00

bis(2,5-dioxopyrrolidin-1-yl) octanedioate

bis(2,5-dioxopyrrolidin-1-yl) octanedioate

from $350.00

from $350.00

CCW16

CCW16

from $580.00

from $580.00

cIAP1 ligand 1

cIAP1 ligand 1

from $640.00

from $640.00

cIAP1 ligand 2

cIAP1 ligand 2

from $850.00

from $850.00

cIAP1 ligand 4

cIAP1 ligand 4

from $840.00

from $840.00

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