Protein Degrader Blocks | PROTAC Tools for Ubiquitin Research – Page 3 – Precise PEG LLC

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Precise PEG LLC

The concurrent binding of a degrader molecule to two proteins—the protein of interest (POI) and an E3 ubiquitin ligase—enables the E3 ligase to recruit the E2 enzyme, initiating polyubiquitination of the POI. This post-translational modification flags the POI for targeted degradation via the proteasome, a central pathway in cellular regulation.

The design of effective PROTACs (proteolysis-targeting chimeras) demands precise control over linker length, shape, and attachment points to optimize binding affinity and functional efficacy. However, the heterobifunctional nature of PROTACs introduces considerable synthetic challenges, and computational tools often fall short in accurately predicting structure-activity relationships (SAR). Consequently, SAR exploration is primarily empirical, necessitating substantial investments of time and resources.

To address the challenges associated with PROTAC design and accelerate development, we have established a robust library of pre-formed E3-ligand linker intermediates. This resource enables the efficient synthesis of a wide array of diverse PROTAC candidates, facilitating their rapid evaluation and optimization for targeted protein degradation applications.

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1050 Results

(R)-N-(2,6-dioxopiperidin-3-yl)-4-(4-(piperidin-4-ylmethyl)piperazin-1-yl)benzamide

(R)-N-(2,6-dioxopiperidin-3-yl)-4-(4-(piperidin-4-ylmethyl)piperazin-1-yl)benzamide

from $1,350.00

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from $1,350.00

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(R)-N-(2,6-dioxopiperidin-3-yl)-5-(4-formylpiperidin-1-yl)picolinamide

(R)-N-(2,6-dioxopiperidin-3-yl)-5-(4-formylpiperidin-1-yl)picolinamide

from $980.00

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from $980.00

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(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-methylbenzamide

(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-methylbenzamide

from $840.00

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from $840.00

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(R)-N-(tert-butoxycarbonyl)-N-(4-(6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-3-yl)benzyl)glycine

(R)-N-(tert-butoxycarbonyl)-N-(4-(6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-3-yl)benzyl)glycine

from $840.00

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from $840.00

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(S)-(S,R,S,R)-AHPC-Me-N3

(S)-(S,R,S,R)-AHPC-Me-N3

from $980.00

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from $980.00

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(S)-1-(3-(piperidin-4-ylmethyl)-2,3,4,4a,5,6-hexahydro-1H-benzo[b]pyrazino[1,2-d][1,4]oxazepin-9-yl)dihydropyrimidine-2,4(1H,3H)-dione

(S)-1-(3-(piperidin-4-ylmethyl)-2,3,4,4a,5,6-hexahydro-1H-benzo[b]pyrazino[1,2-d][1,4]oxazepin-9-yl)dihydropyrimidine-2,4(1H,3H)-dione

from $1,480.00

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from $1,480.00

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(S)-1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidine-4-carbaldehyde

(S)-1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidine-4-carbaldehyde

from $1,580.00

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from $1,580.00

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(S)-2-(((3'-(3-aminothiophen-2-yl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)-N-methyl-2-phenylacetamide

(S)-2-(((3'-(3-aminothiophen-2-yl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)-N-methyl-2-phenylacetamide

from $750.00

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from $750.00

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(S)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-7-hydroxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

(S)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-7-hydroxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

from $850.00

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from $850.00

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(S)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione

(S)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione

from $980.00

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from $980.00

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(S)-2-(4-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperidin-1-yl)acetic acid

(S)-2-(4-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperidin-1-yl)acetic acid

from $1,400.00

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from $1,400.00

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(S)-3-((2-fluoro-4-(piperazin-1-yl)phenyl)amino)piperidine-2,6-dione

(S)-3-((2-fluoro-4-(piperazin-1-yl)phenyl)amino)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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(S)-3-((2S,4R)-4-(fluorosulfonyl)-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamido)-3-(4-(4-methylthiazol-5-yl)phenyl)propanoic acid

(S)-3-((2S,4R)-4-(fluorosulfonyl)-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamido)-3-(4-(4-methylthiazol-5-yl)phenyl)propanoic acid

from $1,480.00

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from $1,480.00

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(S)-3-((3-aminophenyl)amino)piperidine-2,6-dione

(S)-3-((3-aminophenyl)amino)piperidine-2,6-dione

from $1,200.00

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from $1,200.00

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(S)-3-((3-fluoro-4-(piperidin-4-yl)phenyl)amino)piperidine-2,6-dione

(S)-3-((3-fluoro-4-(piperidin-4-yl)phenyl)amino)piperidine-2,6-dione

from $1,200.00

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from $1,200.00

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(S)-3-((3-fluoro-4-(piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

(S)-3-((3-fluoro-4-(piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

from $1,580.00

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from $1,580.00

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(S)-3-((4-(piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

(S)-3-((4-(piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

from $980.00

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from $980.00

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(S)-3-((R)-1-oxo-1,3,5,5a,6,7,8,9-octahydro-2H-pyrazino[1',2':4,5][1,4]oxazino[2,3-e]isoindol-2-yl)piperidine-2,6-dione

(S)-3-((R)-1-oxo-1,3,5,5a,6,7,8,9-octahydro-2H-pyrazino[1',2':4,5][1,4]oxazino[2,3-e]isoindol-2-yl)piperidine-2,6-dione

from $1,450.00

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from $1,450.00

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(S)-3-(1-methyl-6-(piperazin-1-yl)-1H-indazol-3-yl)piperidine-2,6-dione

(S)-3-(1-methyl-6-(piperazin-1-yl)-1H-indazol-3-yl)piperidine-2,6-dione

from $1,450.00

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from $1,450.00

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(S)-3-(1-methyl-6-(piperidin-4-yl)-1H-indazol-3-yl)piperidine-2,6-dione

(S)-3-(1-methyl-6-(piperidin-4-yl)-1H-indazol-3-yl)piperidine-2,6-dione

from $1,980.00

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from $1,980.00

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(S)-3-(1-methyl-6-(piperidin-4-ylamino)-1H-indazol-3-yl)piperidine-2,6-dione

(S)-3-(1-methyl-6-(piperidin-4-ylamino)-1H-indazol-3-yl)piperidine-2,6-dione

from $1,980.00

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from $1,980.00

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(S)-3-(1-oxo-4-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione hydrochloride

(S)-3-(1-oxo-4-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione hydrochloride

from $1,480.00

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from $1,480.00

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(S)-3-(1-oxo-5-(((S)-pyrrolidin-3-yl)oxy)isoindolin-2-yl)piperidine-2,6-dione

(S)-3-(1-oxo-5-(((S)-pyrrolidin-3-yl)oxy)isoindolin-2-yl)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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(S)-3-(1-oxo-5-(2,7-diazaspiro[3.5]nonan-2-yl)isoindolin-2-yl)piperidine-2,6-dione

(S)-3-(1-oxo-5-(2,7-diazaspiro[3.5]nonan-2-yl)isoindolin-2-yl)piperidine-2,6-dione

from $980.00

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from $980.00

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(S)-3-(1-oxo-5-(3,9-diazaspiro[5.5]undecan-3-yl)isoindolin-2-yl)piperidine-2,6-dione

(S)-3-(1-oxo-5-(3,9-diazaspiro[5.5]undecan-3-yl)isoindolin-2-yl)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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(S)-3-(1-oxo-5-(4-((1-(piperidin-4-ylmethyl)piperidin-4-yl)methyl)piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione

(S)-3-(1-oxo-5-(4-((1-(piperidin-4-ylmethyl)piperidin-4-yl)methyl)piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione

from $1,580.00

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from $1,580.00

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(S)-3-(1-oxo-5-(4-(piperidin-4-ylmethyl)piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione

(S)-3-(1-oxo-5-(4-(piperidin-4-ylmethyl)piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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(S)-3-(1-oxo-5-(4-(piperidin-4-ylmethyl)piperidin-1-yl)isoindolin-2-yl)piperidine-2,6-dione

(S)-3-(1-oxo-5-(4-(piperidin-4-ylmethyl)piperidin-1-yl)isoindolin-2-yl)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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(S)-3-(1-oxo-5-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione hydrochloride

(S)-3-(1-oxo-5-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione hydrochloride

from $540.00

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from $540.00

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(S)-3-(1-oxo-5-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione-3,4,4,5,5-d5

(S)-3-(1-oxo-5-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione-3,4,4,5,5-d5

from $2,800.00

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from $2,800.00

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(S)-3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione hydrochloride

(S)-3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione hydrochloride

from $1,280.00

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from $1,280.00

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(S)-3-(1-oxo-6-(4-(piperidin-4-ylmethyl)piperazin-1-yl)phthalazin-2(1H)-yl)piperidine-2,6-dione

(S)-3-(1-oxo-6-(4-(piperidin-4-ylmethyl)piperazin-1-yl)phthalazin-2(1H)-yl)piperidine-2,6-dione

from $1,450.00

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from $1,450.00

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(S)-3-(1-oxo-6-(piperazin-1-yl)phthalazin-2(1H)-yl)piperidine-2,6-dione

(S)-3-(1-oxo-6-(piperazin-1-yl)phthalazin-2(1H)-yl)piperidine-2,6-dione

from $1,350.00

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from $1,350.00

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(S)-3-(3-methyl-2-oxo-5-(piperazin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione

(S)-3-(3-methyl-2-oxo-5-(piperazin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione

from $1,450.00

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from $1,450.00

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(S)-3-(3-methyl-2-oxo-5-(piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione

(S)-3-(3-methyl-2-oxo-5-(piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione

from $1,400.00

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from $1,400.00

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(S)-3-(4-(4-(dimethoxymethyl)piperidin-1-yl)-3-fluorophenyl)piperidine-2,6-dione

(S)-3-(4-(4-(dimethoxymethyl)piperidin-1-yl)-3-fluorophenyl)piperidine-2,6-dione

from $1,850.00

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from $1,850.00

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(S)-3-(4-(4-(dimethoxymethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione

(S)-3-(4-(4-(dimethoxymethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione

from $1,750.00

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from $1,750.00

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(S)-3-(4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione

(S)-3-(4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione

from $1,580.00

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from $1,580.00

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(S)-3-(5-((R)-3-(dimethoxymethyl)pyrrolidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(5-((R)-3-(dimethoxymethyl)pyrrolidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $1,450.00

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from $1,450.00

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(S)-3-(5-(3-(dimethoxymethyl)azetidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(5-(3-(dimethoxymethyl)azetidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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(S)-3-(5-(4-(dimethoxymethyl)piperidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(5-(4-(dimethoxymethyl)piperidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $900.00

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from $900.00

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(S)-3-(5-(4-(dimethoxymethyl)piperidin-1-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(5-(4-(dimethoxymethyl)piperidin-1-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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(S)-3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $980.00

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from $980.00

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(S)-3-(5-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione

(S)-3-(5-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione

from $1,200.00

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from $1,200.00

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(S)-3-(6-(4-(dimethoxymethyl)piperidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(6-(4-(dimethoxymethyl)piperidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $900.00

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from $900.00

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(S)-3-(6-(4-(dimethoxymethyl)piperidin-1-yl)-4-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(6-(4-(dimethoxymethyl)piperidin-1-yl)-4-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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(S)-3-(6-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(6-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

from $900.00

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from $900.00

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(S)-3-(6-oxo-6,8-dihydro-2H,7H-spiro[furo[2,3-e]isoindole-3,4'-piperidin]-7-yl)piperidine-2,6-dione

(S)-3-(6-oxo-6,8-dihydro-2H,7H-spiro[furo[2,3-e]isoindole-3,4'-piperidin]-7-yl)piperidine-2,6-dione

from $1,480.00

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from $1,480.00

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