tert-butyl 6-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

Our commitment to advancing your research is reflected in our comprehensive service for the customization of PEG linkers. We specialize in crafting solutions that precisely align with your unique objectives, offering flexibility in functionality at chain ends and chain length.

Key Features:

• Customized functionality at chain ends (compatible combinations)
• Adjustable chain length to suit your specific needs.

In the event that you do not find a solution that perfectly aligns with your requirements, we encourage you to submit an inquiry using the form provided. Our dedicated team ensures a lead time of within two weeks for most new linker developments.

We offer a comprehensive service for the customization of ADC linkers, ensuring they align precisely with your research objectives.

Our capabilities encompass the incorporation of large varieties of linker-payload attachment, linker-antibody attachment, spacer, and peptide/peptidomimetic linkage.

Should you not find a solution that precisely meets your requirements, we invite you to submit an inquiry.

Designing effective small-molecule degraders requires precise adjustments to ligands and crosslinkers, as minor modifications can significantly impact binding efficiency. Optimizing linker length, shape, and attachment points is critical for successful PROTAC development.

We offer a versatile collection of crosslinker-E3 ligand conjugates with functional groups that allow flexible attachment to target ligands, which enables rapid library generation and screening.

Additionally, we can produce custom crosslinker-E3ligand conjugates on demand, leveraging the ready availability of diverse crosslinkers and E3 ligands.